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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 12174
School of Cognitive Sciences
  Title:   The effects of dopaminergic drugs in the dorsal hippocampus of mice in the nicotine-induced anxiogenic-like response
1.  Mohammad Nasehi
2.  Fatemeh Mafi
3.  Shahrbanoo Oryan
4.  Sima Nasri
5.  Mohammad Reza Zarrindast
  Status:   Published
  Journal: Pharmacology, Biochemistry and Behavior
  Vol.:  98
  Year:  2011
  Pages:   468?473
  Supported by:  IPM
Rationale: Nicotine, an active alkaloid of tobacco has an acetylcholine property that alters anxiety-like behaviors in rodents. Moreover, several investigations suggest that the mesolimbic/cortical dopamine systems to be involved in the drugs affecting anxiety. The dopaminergic modulation of acetylcholine synaptic transmission has also been also suggested by different studies. Furthermore, modulation of such behaviors in rodents may be mediated through the dorsal hippocampus. Objectives: In the present study, a possible role of the dorsal hippocampal acetylcholine receptor mechanism in nicotine's influence on anxiogenic-like responses has been investigated. Methods: During test sessions, the hole-board was used to investigate the effects of SCH23390, sulpiride, SKF38393 and quipirole on nicotine response in mice. Results: Intraperitoneal (i.p.) administration of nicotine (0.5 mg/kg) decreased the number of head dips but had no effect on other behaviors. Intra-dorsal hippocampal injections of ineffective doses of SCH23390 (SCH; 0.125 and 0.25 μg/mouse) or sulpiride (SUL; 0.5 and 0.75 μg/mouse) reversed head dips induced by nicotine but did not impact other exploratory behaviors. Furthermore, co-administration of ineffective doses of SKF38393 (SKF; 4 μg/mouse, dorsal hippocampus) or quipirole (QUI; 0.5 μg/mouse) in conjunction with an ineffective dose of nicotine (0.25 mg/kg, i.p.) decreased head dips induced by nicotine, but were otherwise ineffective. Conclusion: These results may indicate a modulatory effect for the dorsal hippocampus dopamine receptors (D1 and D2) on an anxiogenic-like response induced by nicotine.

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