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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 12168
School of Cognitive Sciences
  Title:   Effects of opioidergic systems upon anxiolytic-like behaviors induced in cholestatic rats
1.  Delaram Eslimi
2.  Sharhbano Oryan
3.  Mohammad Nasehi
4.  Mohammad Reza Zarrindast
  Status:   Published
  Journal: European Journal of Pharmacology
  Vol.:  670
  Year:  2011
  Pages:   180-185
  Supported by:  IPM
Cholestasis is associated with endotoxinemia and elevated serum levels of bile acids, cholesterol, bile salts and opioids. Opioid systems have been reported to modulate anxiety. In the present study, the possible involvement of opioidergic system on anxiolytic-like behaviors induced by cholestasis was investigated. Cholestasis was induced in male Wistar rats by ligation of the main bile duct using two ligatures and transecting the duct at the midpoint between them. A standard elevated plus-maze was used to determine anxiety levels in animals. The data indicated that there is an increase, 13 days (but not 10 days) after bile duct ligation, in the percentage of open arm time (

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