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“School of Cognitive Sciences”

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Paper   IPM / Cognitive Sciences / 12167
School of Cognitive Sciences
  Title:   Involvement of dorsal hippocampal a1-adrenergic receptors in the effect of WIN55,212-2 on memory retrieval in inhibitory avoidance task
1.  Azam Moshfegh
2.  Parvin Babaei
3.  Shahrbano Oryan
4.  Bahram Soltani
5.  Mohammad-Reza Zarrindast
  Status:   Published
  Journal: Neuroscience Letters
  Vol.:  489
  Year:  2011
  Pages:   69-73
  Supported by:  IPM
In the present study, the possible role of a 1-adrenergic receptors of the dorsal hippocampus on WIN55,212-2-induced amnesia in male Wistar rats has been evaluated. As a model of learning, a step-down passive avoidance task was used. Results indicated that post-training or pre-test intra- CA1 administration of WIN55,212-2 (0.25 and 0.5ug/rat) reduced the step-down latency, showing an amnestic response. Amnesia produced by post-training WIN55,212-2 (0.5ug/rat) was reversed by pre-test administration of the same drug dose. Interestingly, pre-test intra-CA1 administration of 1- noradrenergic agonists, phenylephrine alone or with an ineffective dose of WIN55,212-2 (0.25ug/rat) reversed post-training WIN55,212-2 (0.5ug/rat)-induced retrieval impairment. On the other hand, pre-test intra-CA1 microinjection of an a1-adrenergic antagonist, prazosin (0.5ug/rat), 2 min before administration of WIN55,212-2 (0.5ug/rat) inhibited the pre-test WIN55,212-2 response. It may be concluded that a 1-adrenergic receptors of the dorsal hippocampal CA1 regions play an important role in WIN55,212-2-induced amnesia and restoration of memory by pre-test WIN55,212-2 administration.

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