• 1
  • 1
  • 2
  • 6
  • 5
  • 6
  • 3
  • 4
IPM
30
YEARS OLD

“School of Cognitive Sciences”

Back to Papers Home
Back to Papers of School of Cognitive Sciences

Paper   IPM / Cognitive Sciences / 12166
School of Cognitive Sciences
  Title:   Cross state-dependency of learning between WIN55, 212-2 and scopolamine in rat dorsal hippocampus
  Author(s): 
1.  Nida Jamali-Raeufy
2.  Mohammad Nasehi
3.  Mohaddeseh Ebrahimi-ghiri
4.  Mohammad Reza zarrindast
  Status:   Published
  Journal: Neuroscience Letters
  Vol.:  491
  Year:  2011
  Pages:   227-231
  Supported by:  IPM
  Abstract:
In the current study, cross state-dependent learning between the cannabinoid CB1/CB2 receptor agonist WIN55, 212-2 (WIN) and muscarinic receptor antagonist scopolamine (SCO) in a step-through inhibitory avoidance task was investigated. All drugs were injected bilaterally into the dorsal hippocampus (intra-CA1) of rats. Data indicated that the immediate post-training administration of WIN (0.25 and 0.5ug/rat) and SCO (2 and 4 ug/rat) decreased memory consolidation and induced amnesia. Moreover, the amnesia induced by the post-training injections of WIN (0.5ug/rat) or SCO (2ug/rat) was restored by either pre-test injections of WIN (0.25 and 0.5ug/rat) or SCO (2 and 4ug/rat). Furthermore, pre-test co-administration of ineffective doses of WIN (0.1ug/rat) with SCO (1ug/rat) restored amnesia induced by the post-training injections of WIN (0.5ug/rat) or SCO (2ug/rat). In conclusion, the data strongly revealed a cross statedependent learning between WIN and SCO in the rat dorsal hippocampus.

Download TeX format
back to top
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
Clients Logo
scroll left or right