“School of Nano-Sciences”
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| Paper IPM / Nano-Sciences / 11700 |
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he rotary motion of the F0 part of the F0F1-ATPase motor that synthesizes the ATP molecules used by the intracellular stepping motors, such as kinesins, is modeled within a stochastically fluctuating medium via the application of the Langevin dynamics wherein the random intramembrane fluctuations are represented by a white noise. We have investigated the influence of an applied electric field and an applied electric current on this rotary motion, and the subsequent production rate of the ATP molecules. It is seen that the application of a field, or a current, changes both the elastic behavior of the cell membrane and the transmembrane potential. These changes in turn transform the dynamics of the F0 part of the motor. We have found that at low fields, the role of transmembrane potential becomes significant in the production rate of the ATP molecules, whereas at high fields the changes induced in the surface tension of the membrane also contribute to the production rate of the ATP.
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